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The perform of SIK1 in tumorigenesis. SIK1 is really a tumor suppressor gene, which plays an important regulatory function in GNAS, KRAS mutation and LKB1 deletion mediated tumors. SIK1 inhibits CREB mediated transcription and influences most cancers cell proliferation, metabolic reprogramming and inflammatory microenvironment. SIK1 could also boos